HUMAN PAPILLOMA VIRUS. Briefly describe the disease and wha…

HUMAN PAPILLOMA VIRUS. Briefly describe the disease and what the virus does. You need to describe how the virus replicates inside cells. You need to explain what each gene codes for and explain the function of those proteins. The paper should be 7-10 pages and you should have at least 5 references.



The Mechanisms of Human Papillomavirus Replication and the Role of Gene Coding

Human papillomavirus (HPV) is a sexually transmitted infection that affects millions of individuals around the world. There are more than 200 different types of HPV, with some strains causing benign warts and others leading to the development of various cancers, including cervical, anal, and oropharyngeal cancers. Understanding the mechanisms of HPV replication is crucial in developing effective prevention and treatment strategies for this prevalent infection.

HPV Replication Inside Cells:
HPV replicates inside the nucleus of infected cells by exploiting the cellular DNA replication machinery. Upon infecting the host cell, the viral DNA is transported into the nucleus, where it establishes an episomal state, independent of the host genome. The replication of HPV DNA is tightly regulated and relies on the expression of specific viral genes.

Gene Coding and Protein Functions:
The HPV genome consists of early and late regions, each encoding specific proteins necessary for viral replication and virion production. The early region consists of six genes (E1, E2, E4, E5, E6, and E7), while the late region encodes two major genes (L1 and L2).

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